뉴스&간행물

네오이뮨텍, 제넥신, 서울대병원 및 포항공대 연구진 2019 미국암학회(AACR)에서 발표

NeoImmuneTech, Genexine, SNUH and POSTECH researchers Announce Presentations

at the American Association for Cancer Research (AACR) Annual Meeting 2019


— Data presented includes results from preclinical studies and clinical trials with the T cell amplifier Hyleukin-7™ —


April 03, 2019 — ROCKVILLE, Md.--(BUSINESS WIRE)--NeoImmuneTech, Inc. (NIT), a T cell-based therapeutics company, today announced the

presentation of new research at the AACR Annual Meeting, being held March 29 - April 3, 2019 in Atlanta, GA. Study results regarding Hyleukin-7™


(Interleukin-7-hyFc), developed jointly with Korean affiliate company Genexine, Inc. (Genexine), will be presented in two posters.


Presentation Details:
Title: CT045. Hyleukin-7, a long-acting interleukin-7, increased absolute lymphocyte counts after subcutaneous and intramuscular administration in

healthy subjects
Date: April 1, 2019


This poster details Hyleukin-7’s safety profile and T cell boosting effects from the first-in-human study in healthy subjects. Hyleukin-7 administration was

well-tolerated, exhibited dose-dependent increases in T cells, and significantly increased killer and memory T cells, which are crucial for effective anti-

tumor response. Additionally, the poster reports that dose escalation of Hyleukin-7 in multiple ongoing clinical trials in cancer patients has shown similar

safety profiles to the first-in-human study, and also demonstrated dose-dependent increases of killer T cells. The study was led by professor Howard Lee

of Seoul National University Hospital (SNUH).


Title: 4991. Hyleukin-7, the Fc-fused interleukin-7, generates anti-tumor activity by modulating both adaptive and innate immune cells in the tumor

microenvironment
Date: April 3, 2019


Data shown here focuses on the anti-cancer mechanism of Hyleukin-7 from preclinical studies. Hyleukin-7 affected the immune cells not only in the

peripheral blood but also in the tumor microenvironment (TME). This study, led by professor Seung-Woo Lee of Pohang University of Science and

Technology (POSTECH), Korea, demonstrated that administration of Hyleukin-7 in an animal cancer model significantly increased the quantity of killer T

cells. Most importantly, within the TME killer T cells drastically increased while regulatory T cells and myeloid lineage cells (immune suppressor cells)

such as myeloid-derived suppressor cells (MDSC) substantially decreased, resulting in significant anti-tumor activity.


"This research is the first to demonstrate that a long-acting IL-7 effectively modulates the TME, significantly amplifying anti-tumor T cells and reducing

immune-suppressive cells such as MDSCs in the tumor," said professor Seung-Woo Lee. "These data allow us to envision Hyleukin-7 as a potential

next-generation cancer immunotherapy with a differentiated function.”


“Having recently raised $92 million in Series D funding round, we aim to use the funds to continue confirming the anti-tumor effects and mode of

action of Hyleukin-7 through multiple monotherapy and combination therapy clinical trials in various tumor types,” added Se Hwan Yang, Ph.D.,

Chief Executive Officer of NIT.


NIT and Genexine are currently conducting dose-escalation studies to identify an optimal Hyleukin-7 dosing regimen in advanced solid tumors and brain

cancer (glioblastoma) patients. NIT and Genexine are also collaborating with global pharmaceutical companies to combine Hyleukin-7 with anti-PD-1/anti-

PD-L1 therapies in clinical trials in high-risk skin cancers and triple-negative breast cancer patients in the United States and Korea, respectively.


About Hyleukin-7™
Hyleukin-7™ (rhIL-7-hyFc, NT-I7), an immuno-oncology agent, is a T cell growth factor composed of a covalently linked homodimer of engineered

Interleukin-7 (IL-7) molecule, biologically fused with the proprietary long-acting platform – hyFc™. IL-7 is known to be a critical factor for T cells

homeostasis, acting to increase both the number and functionality of T cells. Hyleukin-7 amplifies and reinvigorates persistent T cell immunity in the

treatment of patients with cancer and lymphopenia, thus providing unique opportunities for immuno-oncology (IO) combination strategies. Hyleukin-7 is

being developed as an “IO enabling” therapy to harness T cell immunity in combination with current cancer treatments such as anti-PD-(L)1 agents or

chemo/radiotherapy as well as next generation IO therapeutics.


About NeoImmuneTech, Inc.
NeoImmuneTech (NIT) is developing T cell-based therapeutics designed to prime, enhance and extend the activity of current and future cancer therapies.

Our lead product, Hyleukin-7™, a T cell growth factor, amplifies and reinvigorates persistent anti-tumor activity, which is pivotal to extending survival of

cancer patients. Hyleukin-7 is being studied in multiple clinical trials in solid tumors, and being planned for testing in hematologic malignancies,

additional solid tumors and other immunology-focused indications. www.neoimmunetech.com
NIT is a U.S.-based company developing Hyleukin-7 for the U.S. and EU markets in collaboration with Korean-based Genexine.

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